Clinical features and immune-related protein patterns of anti-MDA5 positive clinically amyopathic dermatomyositis Dutch patients.

Marjolein P M HensgensEveline M DelemarreJulia DrylewiczMareye VoortmanRoline M KrolVirgil A S H DalmJelle R MiedemaIvo WiertzJan GruttersMaarten LimperStefan NierkensHelen L Leavis

Published in: Rheumatology (Oxford, England) (2022)

In this Dutch anti-MDA5 positive clinically amyopathic DM (CADM) cohort, one-third of the patients died due to RPILD soon after diagnosis, which underlines the severity of this disease. In addition, we have found several possible pathways that are differentially regulated in RPILD vs no RPILD DM and healthy controls. These markers await further validation before clinical use.

Keyphrases

end stage renal disease
newly diagnosed
chronic kidney disease
ejection fraction
interstitial lung disease
peritoneal dialysis
patient reported outcomes
systemic sclerosis
rheumatoid arthritis
cell death
weight loss