Spliceosome-regulated RSRP1-dependent NF-κB activation promotes the glioblastoma mesenchymal phenotype.

Yaomin LiXiran WangSong-Tao QiLei GaoGuanglong HuangZhonglu RenKaishu LiYuping PengGuozhong YiJinglin GuoRunwei YangHai WangXian ZhangYa-Wei Liu

Published in: Neuro-oncology (2021)

We identified a novel mechanism through which RSRP1-dependent splicing promotes the GBM MES phenotype. Targeting AS via RSRP1-related spliceosomal factors might constitute a promising treatment for GBM.

Keyphrases

signaling pathway
stem cells
bone marrow
oxidative stress
transcription factor
cancer therapy
nuclear factor
immune response