A cell cycle regulator, E2F2, and glucocorticoid receptor cooperatively transactivate the bovine alphaherpesvirus 1 immediate early transcription unit 1 promoter.

Published in: Journal of virology (2024)

-regulatory module (CRM) in the IEtu1 promoter that contains two GR responsive elements. Chromatin immunoprecipitation studies revealed that E2F2 occupies IEtu1 promoter sequences in cultured cells. GR and E2F2 mediate cooperative transactivation of IEtu1 promoter activity, which is predicted to stimulate viral replication following stressful stimuli.

Keyphrases

transcription factor
cell cycle
dna methylation
gene expression
cell proliferation
induced apoptosis
genome wide
sars cov
cancer therapy
cell cycle arrest
signaling pathway
oxidative stress
endoplasmic reticulum stress
binding protein
genetic diversity