Impaired efferocytosis by synovial macrophages in patients with knee osteoarthritis.

Luigi Del SordoGarth B BlacklerHolly T PhilpottJared RiviereLakshman GunaratnamBryan HeitChristopher Thomas Appleton

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

Apoptotic cells accumulate in the synovium of patients with late-stage knee OA. Our results suggest that OA impairs critical homeostatic functions of synovial macrophages leading to accumulation of apoptotic cells. This article is protected by copyright. All rights reserved.

Keyphrases

knee osteoarthritis
induced apoptosis
cell cycle arrest
cell death
total knee arthroplasty
endoplasmic reticulum stress
signaling pathway
oxidative stress
anti inflammatory
pi k akt