The PI3K pathway impacts stem gene expression in a set of glioblastoma cell lines.

Eduardo MartinezNeftali VazquezAlma LopezVictor FannielLilia SanchezRebecca MarksLeetoria HinojosaVictoria CuelloMarisa CuevasAngelica RodriguezCerin TomsonAndrea SalinasMark AbadMartin HolguinNoel GarzaAbraham ArenasKevin AbrahamLuis MaldonadoVivian RojasAlex BasdeoErin SchuenzelMichael PersansWendy Innis-WhitehouseMegan Keniry

Published in: Journal of cancer research and clinical oncology (2020)

Given that, PI3K inhibitors are actively investigated as targeted cancer therapies, the FOXO-mediated induction of stem genes observed in this study highlights a potential hazard to PI3K inhibition. Understanding the molecular underpinnings of stem signatures in cancer will allow refinements to therapeutic strategies. Targeting FOXO factors to reduce stem cell characteristics in concert with PI3K inhibition may prove therapeutically efficacious.

Keyphrases

gene expression
papillary thyroid
stem cells
squamous cell
transcription factor
genome wide
cancer therapy
signaling pathway
dna methylation
pi k akt
squamous cell carcinoma
cell proliferation
risk assessment
drug delivery
atomic force microscopy
climate change
mesenchymal stem cells
bone marrow
high speed