The Relationship of Kidney Tubule Biomarkers with Brain Imaging in CKD Patients in SPRINT.
Lindsay M MillerManjula Kurella TamuraNicholas M PajewskiDena RifkinDaniel E WeinerMaria MarquineMichael G ShlipakJoachim H IxPublished in: Kidney360 (2021)
Urine biomarker concentrations reflecting kidney tubule injury and dysfunction were not associated with brain MRI measures.Higher eGFR was associated with lower total brain cerebral blood flow.This is the first evaluation of the relationship of kidney tubule biomarkers with brain imaging by MRI in patients with CKD.
Keyphrases
- resting state
- white matter
- chronic kidney disease
- end stage renal disease
- functional connectivity
- high resolution
- cerebral blood flow
- magnetic resonance imaging
- cerebral ischemia
- newly diagnosed
- ejection fraction
- oxidative stress
- epidermal growth factor receptor
- computed tomography
- diffusion weighted imaging
- multiple sclerosis
- high intensity
- magnetic resonance
- brain injury
- mass spectrometry