Placebo Response in Rheumatoid Arthritis Clinical Trials.
Katie BechmanMark YatesKatherine JonesAndrew P CopeJames B GallowayPublished in: The Journal of rheumatology (2019)
There has been a rise in the placebo response in RA clinical trials over the last 2 decades. Shifting RA phenotype, changes in trial design, and expectation bias are possible explanations for this phenomenon. This observation has important implications when evaluating newer novel agents against established therapies.