Alveolar-arterial oxygen gradient: An early marker to predict the severity of community-acquired pneumonia in children.
Baoxi ZhaoMingqiang SiZhonghua HuJunsheng JiangPublished in: Medicine (2024)
To study the clinical significance of alveolar-arterial oxygen gradient (PA-aO2) for children with community-acquired pneumonia (CAP). A prospective study was carried out from January 2020 to June 2023, Overall, 100 patients were included in the study, 35 had severe pneumonia, whereas, 65 had non-severe pneumonia. Clinical and laboratory data were retrospectively collected at the time of hospital admission and during hospitalization. Patients were divided into severe and non-severe groups. PA-aO2 was significantly higher among children with severe pneumonia, as determined by WHO, PRESS (P < .001). PA-aO2 was significantly higher among children with mechanical ventilation, shock, sepsis, and mortality. Receiver operating characteristic curve (ROC) analysis for PA-aO2 showed that the area under the curve was 0.76 (P value < .05), with a sensitivity of 84.3% and a specificity of 67.9%. Our study suggests that PA-aO2 level has a predictive value for detecting community-acquired pneumonia severity in children.
Keyphrases
- community acquired pneumonia
- young adults
- end stage renal disease
- mechanical ventilation
- early onset
- ejection fraction
- newly diagnosed
- intensive care unit
- prognostic factors
- peritoneal dialysis
- healthcare
- acute respiratory distress syndrome
- acute kidney injury
- cardiovascular disease
- respiratory failure
- type diabetes
- big data
- machine learning
- acute care
- adverse drug
- artificial intelligence
- extracorporeal membrane oxygenation