Mortality Associated with Recurrent Extreme Hyperferritinemia in Critically Ill Adolescents.

Recurrent extreme hyperferritinemia-often with multiple organ dysfunction syndrome-was noted in 4 adolescents with systemic inflammation who did not survive their critical illness. Recurrent extreme hyperferritinemia may be a novel biomarker of increased mortality in patients with the syndrome of persistent inflammation, immunosuppression, and catabolism.