Login / Signup

Ca 2+ dysregulation in cardiac stromal cells sustains fibro-adipose remodeling in Arrhythmogenic Cardiomyopathy and can be modulated by flecainide.

Angela Serena MaionePawan FarisLara IengoValentina CattoLuca BisonniFrancesco LodolaSharon NegriMichela CasellaAnna GuarinoGianluca PolvaniMarina CerroneClaudio TondoGiulio PompilioElena SommarivaFrancesco Moccia
Published in: Journal of translational medicine (2022)
dysregulation in ACM to the stromal compartment, as an etiologic mechanism of C-MSC-related ACM phenotypes. A new mode of action of flecainide on a novel mechanistic target is unveiled against the fibro-adipose accumulation in ACM.
Keyphrases
  • adipose tissue
  • insulin resistance
  • heart failure
  • bone marrow
  • left ventricular
  • metabolic syndrome
  • protein kinase