Ca 2+ dysregulation in cardiac stromal cells sustains fibro-adipose remodeling in Arrhythmogenic Cardiomyopathy and can be modulated by flecainide.

Angela Serena MaionePawan FarisLara IengoValentina CattoLuca BisonniFrancesco LodolaSharon NegriMichela CasellaAnna GuarinoGianluca PolvaniMarina CerroneClaudio TondoGiulio PompilioElena SommarivaFrancesco Moccia

Published in: Journal of translational medicine (2022)

dysregulation in ACM to the stromal compartment, as an etiologic mechanism of C-MSC-related ACM phenotypes. A new mode of action of flecainide on a novel mechanistic target is unveiled against the fibro-adipose accumulation in ACM.

Keyphrases

adipose tissue
insulin resistance
heart failure
bone marrow
left ventricular
metabolic syndrome
protein kinase