Sodium-glucose cotransporter 1 as a sugar taste sensor in mouse tongue.

Keiko YasumatsuTadahiro OhkuriRyusuke YoshidaShusuke IwataRobert F MargolskeeYuzo Ninomiya

Published in: Acta physiologica (Oxford, England) (2020)

We found evidence for the contribution of SGLTs in sugar sensing in taste cells of mouse tongue. Moreover, we found T1R-dependent (Phl-insensitive) type, Glc-type and Mixed (SGLTs and T1Rs)-type fibres. SGLT1 may be involved in the latter two types and may play important roles in the glucose-specific cephalic phase of digestion and palatable food intake.

Keyphrases

induced apoptosis
oxidative stress
blood glucose
skeletal muscle
endoplasmic reticulum stress
weight loss
anaerobic digestion