The side and the location of the primary tumor does not affect the probability of lymph node invasion in patients with renal cell carcinoma.

Patients with single-side and more than one anatomical kidney area affected by RCC have higher rate of LNI at surgery and/or NP at follow-up. Neither side nor location of primary RCC tumor is related to the risk of harboring LNI at surgery and/or developing NP at follow-up.