Engystol reduces onset of experimental respiratory syncytial virus-induced respiratory inflammation in mice by modulating macrophage phagocytic capacity.
Sabine WronskiJulia DannenmaierSabine SchildOlaf MackeLaura MüllerYvonne BurmeisterBernd SeilheimerMeike MüllerPublished in: PloS one (2018)
The data suggest a beneficial immunomodulatory effect of EGY-2 during early onset of respiratory viral infection in vivo, mediated by stimulation of macrophage phagocytosis, resulting in a reduced innate inflammatory response in terms of neutrophil and early lymphocyte infiltration as well as reduced inflammatory cytokine secretion.
Keyphrases
- early onset
- respiratory syncytial virus
- inflammatory response
- oxidative stress
- late onset
- immune response
- diabetic rats
- adipose tissue
- high glucose
- lipopolysaccharide induced
- respiratory tract
- signaling pathway
- high fat diet induced
- electronic health record
- lps induced
- big data
- toll like receptor
- type diabetes
- endothelial cells
- artificial intelligence