Self-Assembled Human Skin Equivalents Model Macrophage Activation of Cutaneous Fibrogenesis in Systemic Sclerosis.
Mengqi HuangAvi SmithMatthew WatsonRajan BhandariLauren M BaughIrena IvanovskaTrishawna WatkinsIrene LangMaria TrojanowskaLauren D BlackPatricia A PioliJonathan GarlickMichael L WhitfieldPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
These data suggest reciprocal activation between macrophages and fibroblasts that increases tissue thickness and stiffness, which is dependent in part on TGFβ activation. The saSE system may serve as a platform for preclinical therapeutic testing and for molecular characterization of SSc skin pathology through recapitulation of the interactions between macrophages and fibroblasts.
Keyphrases
- systemic sclerosis
- interstitial lung disease
- extracellular matrix
- optical coherence tomography
- adipose tissue
- machine learning
- stem cells
- transforming growth factor
- mesenchymal stem cells
- big data
- idiopathic pulmonary fibrosis
- bone marrow
- deep learning
- epithelial mesenchymal transition
- artificial intelligence
- data analysis