Spermidine ameliorates colitis via induction of anti-inflammatory macrophages and prevention of intestinal dysbiosis.

Anna NiechcialMarlene SchwarzfischerMarcin WawrzyniakKirstin AtrottAndrea LaimbacherYasser MorsyEgle KatkeviciuteJanine HäfligerPatrick WestermannCezmi A AkdisMichael ScharlMarianne Rebecca Spalinger

Published in: Journal of Crohn's & colitis (2023)

Spermidine reduces intestinal inflammation by promoting anti-inflammatory macrophages, maintaining a healthy microbiome, and preserving epithelial barrier integrity in a PTPN2-dependent manner.

Keyphrases

anti inflammatory
oxidative stress
mouse model
ulcerative colitis