Dual oxidase 1 limits the IFNγ-associated antitumor effect of macrophages.

Lydia MezianiMarine Gerbé de ThoréPauline HamonSophie BockelRuy A LouzadaCéline ClemensonRaphaël CorreWinchygn LiuCorinne DupuyMichele MondiniEric Deutsch

Published in: Journal for immunotherapy of cancer (2021)

Our data indicate that DUOX1 is a new target for macrophage reprogramming and suggest that DUOX1 inhibition in macrophages combined with RT is a new therapeutic strategy for the management of cancers.

Keyphrases

immune response
electronic health record
dendritic cells
adipose tissue
big data
machine learning
artificial intelligence
childhood cancer