Prevalence and Prognosis of Lynch Syndrome and Sporadic Mismatch Repair Deficiency in Endometrial Cancer.
Cathalijne C B PostEllen StellooVincent T H B M SmitDina RuanoCarli M TopsLisa VermijTessa A RuttenIna M Jürgenliemk-SchulzLudy C H W LutgensJan J JobsenRemi A NoutEmma J CrosbieMelanie E PowellLinda MileshkinAlexandra LearyPaul BessetteHein PutterStephanie M de BoerNanda HorewegMaartje NielsenTom van WezelTjalling BosseCarien L CreutzbergPublished in: Journal of the National Cancer Institute (2022)
The LS prevalence in the Post Operative Radiation Therapy in Endometrial Carcinoma trial population was 2.8% and among MMRd-ECs was 9.5%. Patients with LS-associated ECs showed a trend towards better recurrence-free survival and higher risk for second cancers compared with patients with MLH1-hypermethylated MMRd-EC.