Morphine induces inflammatory responses via both TLR4 and cGAS-STING signaling pathways.
Fei XieYoshinori KitagawaHiroki OgataShingo YasuharaZerong YouJ A Jeevendra Martyn
Published in: Cytokine (2024)
Morphine activates the cGAS-STING pathway in macrophage cell types. Inhibition of the STING pathway can be an additional method to overcome immune cell inflammation-related morphine tolerance and opioid-induced hyperalgesia.