Multi-Tissue Epigenetic and Gene Expression Analysis Combined With Epigenome Modulation Identifies RWDD2B as a Target of Osteoarthritis Susceptibility.
Eleanor ParkerInes M J HoferSarah J RiceLucy EarlSami A AnjumDavid J DeehanJohn LoughlinPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
The rs6516886 association signal is a multi-tissue meQTL involving cg20220242 and acting on RWDD2B. Modulating CpG methylation reverses the impact of the risk allele. RWDD2B codes for a protein about which little is currently known. Its further analysis as a target of OA genetic risk will provide novel insight into this complex disease.