Ameliorative effect of hesperidin against high dose sildenafil-induced liver and testicular oxidative stress and altered gene expression in male rats.

Ibrahim M Ibrahim Laila Samar Hassab-Allah Kassem Marwa Salah ElDin Mohamed Diab

Published in: Laboratory animal research (2023)

Hesperidin attenuated the harmful effects of intensive sildenafil citrate treatment on liver and testicular functions, alleviated oxidative stress and normalized blood indices. Therefore, hesperidin could be protective against sildenafil citrate-induced oxidative damage that may develop over the long term.

Keyphrases

diabetic rats
oxidative stress
gene expression
high dose
pulmonary hypertension
pulmonary arterial hypertension
high glucose
dna damage
low dose
drug induced
ischemia reperfusion injury
endothelial cells
germ cell
induced apoptosis
stem cell transplantation
signaling pathway
combination therapy
heat stress