Pharmacogenomic Score Effectively Personalizes Treatment of Acute Myeloid Leukemia.

Richard James Marrero Huiyun Wu Xueyuan Cao Phani Krishna Parcha Abdelrahman H Elsayed Hiroto Inaba Dennis John Kuo Barbara A Degar Kenneth M Heym Jeffrey W Taub Norman J Lacayo Ching-Hong Pui Raul C Ribeiro Jeffrey E Rubnitz Stanley B Pounds Jatinder Kaur Lamba

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Our findings suggest that tailoring induction regimens using ACS10 scores can significantly improve outcome in patients with AML. Given the SNPs are germline, preemptive genotyping can accelerate matching the most effective remission induction regimen.

Keyphrases

acute myeloid leukemia
genome wide
allogeneic hematopoietic stem cell transplantation
acute coronary syndrome
high throughput
dna repair
disease activity
gene expression
clinical decision support
ulcerative colitis
systemic lupus erythematosus