Salt Triggered Adaptive Dissociation Coating with Dual Effect of Antibacteria and Anti-multiple Encrustations in Urological Devices.

Bacterial infections and multiple encrustations are life-threatening complications in patients implanted with urological devices. Limited by time-consuming procedures and substrate dependence, it is difficult to simultaneously prevent the aforementioned complications. Herein, we report the design of a salt-triggered chondroitin sulfate complex (CS/Si-N + ) coating with adaptive dissociation, which realizes the dual functions of antibacterial and anti-multiple encrustations in urological devices with arbitrary shapes. The existence of covalent interactions between the complex and the interface ensured the formation of a robust coating, especially in harsh environments. Benefiting from the adaptive dissociation of the ion pairs in the CS/Si-N + coating in urine electrolytes, the exposed ion groups and enhanced hydrophilicity were more conducive to the inhibition of bacterial infection and multiple encrustations simultaneously. The coating exhibited broad-spectrum bactericidal effects. As a proof of concept, in a simulated metabolic encrustation model, the coating exhibited significant advantages in resisting calcium oxalate encrustation, with a reduction in the calcium content by over 90%. In addition, this non-leachable all-in-one coating showed good biocompatibility in a pig in vivo model. Such a coating strategy is expected to be a practical approach for preventing urological medical device-related complications. This article is protected by copyright. All rights reserved.