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Optimizing CAR-T cell Culture: Differential effects of IL-2, IL-12, and IL-21 on CAR-T cells.
Mengmeng Zhang
JingJing Kong
Fanxiang Yin
Jianxiang Shi
Jin Li
Zan Qiu
Baohong Yue
Shuya Wang
Nannan Sun
Quande Lin
Liyan Fu
Xiaoqian Wang
Xianlei Sun
Yanxia Gao
Yong Jiang
Rongqun Guo
Published in:
Cytokine (2024)
Our findings suggest that IL-21 may play a role in preventing senescence and could be utilized in combination with other strategies, such as IL-2 and IL-12, for CAR-T culture.
Keyphrases
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induced apoptosis
dna damage
endothelial cells
endoplasmic reticulum stress