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Discussion on "Spatial+: a novel approach to spatial confounding" by Emiko Dupont, Simon N. Wood, and Nicole H. Augustin.

Georgia Papadogeorgou
Published in: Biometrics (2022)
I congratulate Dupont, Wood, and Augustin (DWA hereon) for providing an easy-to-implement method for estimation in the presence of spatial confounding, and for addressing some of the complicated aspects on the topic. I discuss conceptual and operational issues that are fundamental to inference in spatial settings: (i) the target quantity and its interpretability, (ii) the nonspatial aspect of covariates and their relative spatial scales, and (iii) the impact of spatial smoothing. While DWA provide some insights on these issues, I believe that the audience might benefit from a deeper discussion.
Keyphrases
  • single cell