β-Cell function in obese children and adolescents with metabolic syndrome compared to isolated obesity.
Guo-Hua LiXue-Feng ChenXin-Yi LiangHu LinLi ZhangXiao-Qin XuWei WuKe HuangGuan-Ping DongJian-Wei ZhangSusan R RoseRahim UllahPhilip S ZeitlerJun-Fen FuPublished in: Pediatric diabetes (2019)
Although the MS youth have β-cell hyperfunction as a whole, β-cell dysfunction is present in the early stages of dysmetabolism in obese youth with cMD or MS and worsened across the spectrum from iOB to cMD and MS, contributing to development of T2DM.
Keyphrases
- metabolic syndrome
- mass spectrometry
- weight loss
- multiple sclerosis
- ms ms
- insulin resistance
- single cell
- adipose tissue
- type diabetes
- physical activity
- mental health
- cell therapy
- young adults
- uric acid
- bariatric surgery
- oxidative stress
- obese patients
- cardiovascular disease
- mesenchymal stem cells
- high fat diet induced