Magnetically Guided Viral Transduction of Gene-Based Sensitization for Localized Photodynamic Therapy To Overcome Multidrug Resistance in Breast Cancer Cells.
Zi-Xian LiaoIvan M KempsonYu-Chen FaMeng-Chia LiuLi-Chen HsiehKuo-Yen HuangLi-Feng WangPublished in: Bioconjugate chemistry (2017)
Chemotherapy represents a conventional treatment for many cancers at different stages and is either solely prescribed or concomitant to surgery, radiotherapy, or both. However, treatment is tempered in instances of acquired drug resistance in response to either chemotherapy or targeted therapy, leading to therapeutic failure. To overcome this challenge, many studies focus on how cancer cells manipulate their genomes and metabolism to prevent drug influx and facilitate the efflux of accumulated chemotherapy drugs. Herein, we demonstrate magnetic adeno-associated virus serotype 2 (ironized AAV2) has an ability to be magnetically guided and transduce the photosensitive KillerRed protein to enable photodynamic therapy irrespective of drug resistance.
Keyphrases
- photodynamic therapy
- locally advanced
- early stage
- squamous cell carcinoma
- radiation therapy
- minimally invasive
- rectal cancer
- young adults
- fluorescence imaging
- gene expression
- coronary artery disease
- gene therapy
- escherichia coli
- copy number
- multidrug resistant
- molecularly imprinted
- coronary artery bypass
- replacement therapy
- protein protein
- surgical site infection