Pharmacokinetics and pharmacodynamics of high-dose isoniazid for the treatment of rifampicin- or multidrug-resistant tuberculosis in Indonesia.

Vycke YunivitaFajri GafarPrayudi SantosoLidya ChaidirArto Y SoerotoTriana N MeirinaLindsey Te BrakeDick MenziesRob E AarnoutseRovina Ruslami

Published in: The Journal of antimicrobial chemotherapy (2024)

Isoniazid exposures below targets were observed in most patients, and certain risk groups for low isoniazid exposures may require dose adjustment. The effect of low isoniazid exposures on delayed culture conversion deserves attention.

Keyphrases

mycobacterium tuberculosis
air pollution
high dose
multidrug resistant
pulmonary tuberculosis
end stage renal disease
chronic kidney disease
ejection fraction
newly diagnosed
low dose
prognostic factors
peritoneal dialysis
emergency department
working memory
klebsiella pneumoniae
hiv aids