Noninvasive and early diagnosis of acquired brain injury using fluorescence imaging in the NIR-II window.
Xinyan JiangRui PuCheng WangJiale XuYaohui TangShuhong QiQiuqiang ZhanXunbin WeiBobo GuPublished in: Biomedical optics express (2021)
Acquired brain injury (ABI), which is the umbrella term for all brain injuries, is one of the most dangerous diseases resulting in high morbidity and mortality, making it extremely significant to early diagnosis of ABI. Current methods, which are mainly composed of X-ray computed tomography and magnetic resonance angiography, remain limited in diagnosis of ABI with respect to limited spatial resolution and long scanning times. Here, we reported through-skull fluorescence imaging of mouse cerebral vasculature without craniotomy, utilizing the fluorescence of down-conversion nanoparticles (DCNPs) in the 1.3 - 1.7 μm near-infrared window (NIR-II window). Due to its high spatial resolution of 22.79 μm, the NIR-II fluorescence imaging method could quickly distinguish the brain injury region of mice after performing the stab wound injury (traumatic brain injury) and ischemic stroke (non-traumatic brain injury), enabling it a powerful tool in the noninvasive and early diagnosis of ABI.
Keyphrases
- fluorescence imaging
- brain injury
- traumatic brain injury
- subarachnoid hemorrhage
- photodynamic therapy
- cerebral ischemia
- computed tomography
- magnetic resonance
- single molecule
- high resolution
- dual energy
- positron emission tomography
- preterm infants
- optical coherence tomography
- magnetic resonance imaging
- atrial fibrillation
- contrast enhanced
- type diabetes
- multiple sclerosis
- adipose tissue
- resting state
- high fat diet induced
- pet ct