Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice.
Mickael AudrainJean-Vianney Haure-MirandeJustyna MleczkoMinghui WangJennifer K GriffinPeter H St George-HyslopPaul FraserBin ZhangSamuel E GandyMichelle E EhrlichPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2020)
Our results provide evidence that TYROBP-APOE signaling does not require TREM2 and could be an initiating step in establishment of the disease-associated microglia (DAM) phenotype.