Effect of chronic intermittent hypoxia on ocular and intraoral mechanical allodynia mediated via the calcitonin gene-related peptide in a rat.

Ayano KatagiriSaki KishimotoYoshie OkamotoMasaharu YamadaHitoshi NiwaDavid A BereiterTakafumi Kato

Published in: Sleep (2024)

An increase in CGRP in the TG induced by CIH, as well as orofacial mechanical allodynia and central sensitization of second-order neurons in the Vc, supported the notion that CGRP plays a critical role in CIH-induced orofacial mechanical allodynia.

Keyphrases

neuropathic pain
spinal cord
drug induced
high glucose
oxidative stress
endothelial cells
genome wide
high intensity
dna methylation
transcription factor
genome wide identification