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Effect of chronic intermittent hypoxia on ocular and intraoral mechanical allodynia mediated via the calcitonin gene-related peptide in a rat.

Ayano KatagiriSaki KishimotoYoshie OkamotoMasaharu YamadaHitoshi NiwaDavid A BereiterTakafumi Kato
Published in: Sleep (2024)
An increase in CGRP in the TG induced by CIH, as well as orofacial mechanical allodynia and central sensitization of second-order neurons in the Vc, supported the notion that CGRP plays a critical role in CIH-induced orofacial mechanical allodynia.
Keyphrases
  • neuropathic pain
  • spinal cord
  • drug induced
  • high glucose
  • oxidative stress
  • endothelial cells
  • genome wide
  • high intensity
  • dna methylation
  • transcription factor
  • genome wide identification