Hypoxia Effects in Intervertebral Disc-Derived Stem Cells and Discus Secretomes: An in vitro Study.
null RomaniyantoFerdiansyah MahyudinCita Rosita Sigit PrakoeswaHari Basuki NotobrotoDamayanti TinduhRyan AusrinFedik Abdul RantamHeri SurotoDwikora Novembri UtomoSholahuddin RhatomyPublished in: Stem cells and cloning : advances and applications (2022)
Oxygen level in hypoxia preconditioning has a role in the preparation of IVDSCs and secretome preparation in vitro. The highest cell numbers were found in the treatment group with 3% hypoxia, and 3% hypoxia was significantly related to support IVDSCs preparation. Preconditioning with 3% hypoxia had higher PDGF and VEGF levels than other hypoxia groups.