Stereotactic Photodynamic Therapy Using a Two-Photon AIE Photosensitizer.
Xiaojing HeBo SituMeng GaoShujuan GuanBairong HeXiaoxue GeShiwu LiMaliang TaoHang ZouBen-Zhong TangLei ZhengPublished in: Small (Weinheim an der Bergstrasse, Germany) (2019)
Two-photon photodynamic therapy (TP-PDT) is emerging as a powerful strategy for stereotactic targeting of diseased areas, but ideal photosensitizers (PSs) are currently lacking. This work reports a smart PS with aggregation-induced emission (AIE) feature, namely DPASP, for TP-PDT with excellent performances. DPASP exhibits high affinity to mitochondria, superior photostability, large two-photon absorption cross section as well as efficient reactive oxygen species generation, enabling it to achieve photosensitization both in vitro and in vivo under two-photon excitation. Moreover, its capability of stereotactic ablation of targeted cells with high-precision is also successfully demonstrated. All these merits make DPASP a promising TP-PDT candidate for accurate ablation of abnormal tissues with minimal damages to surrounding areas in the treatment of various diseases.
Keyphrases
- photodynamic therapy
- living cells
- reactive oxygen species
- fluorescent probe
- fluorescence imaging
- brain metastases
- induced apoptosis
- single molecule
- cancer therapy
- monte carlo
- machine learning
- cell death
- gene expression
- small cell lung cancer
- cell cycle arrest
- high resolution
- drug delivery
- emergency department
- catheter ablation
- endoplasmic reticulum stress
- endoplasmic reticulum
- oxidative stress
- cell proliferation
- electronic health record