Alzheimer's disease as an inflammatory disease.
Marta BolósJuan Ramón PereaJesús AvilaPublished in: Biomolecular concepts (2017)
Alzheimer's disease (AD) is a neurodegenerative condition characterized by the formation of amyloid-β plaques, aggregated and hyperphosphorylated tau protein, activated microglia and neuronal cell death, ultimately leading to progressive dementia. In this short review, we focus on neuroinflammation in AD. Specifically, we describe the participation of microglia, as well as other factors that may contribute to inflammation, in neurodegeneration.
Keyphrases
- cell death
- oxidative stress
- cognitive decline
- multiple sclerosis
- inflammatory response
- traumatic brain injury
- neuropathic pain
- mild cognitive impairment
- physical activity
- cognitive impairment
- spinal cord injury
- cell proliferation
- signaling pathway
- cerebral ischemia
- cerebrospinal fluid
- brain injury
- subarachnoid hemorrhage
- lps induced
- pi k akt
- cell cycle arrest