Hyperactivation and altered selection of B cells in patients with paediatric Sjogren's syndrome.

Alessandra BoniRebecca NicolaiIvan CaielloFrancesca MarinaroLuciapia FarinaDenise Pires MarafonRita CarsettiFabrizio De BenedettiClaudia Bracaglia Emiliano Marasco

Published in: RMD open (2024)

Our results point to a hyperactivation of B cells in pSS. Current therapies do not seem to affect B cell abnormalities, suggesting that novel therapies targeting specifically B cell hyperactivation need to be implemented for paediatric patients.

Keyphrases

end stage renal disease
intensive care unit
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
cancer therapy