Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy.
Elham Beyranvand NejadCamilla LabrieZiena AbdulrahmanMarit J van ElsasEva RademakerJan Willem KleinovinkTetje C van der SluisSuzanne van DuikerenAmina F A S TeunisseAart G JochemsenJan OostingNoel F C C de MirandaThorbald van HallRamon ArensSjoerd H Van der BurgPublished in: Journal for immunotherapy of cancer (2021)
An immunotherapy-induced disability of tumor cells to attract innate myeloid effector cells formed a major mechanism underlying immune escape and acquired resistance. These data not only stresses the importance of myeloid effector cells during immunotherapy but also demands for new studies to harness their tumoricidal activities.
Keyphrases
- dendritic cells
- induced apoptosis
- bone marrow
- cell cycle arrest
- acute myeloid leukemia
- immune response
- regulatory t cells
- multiple sclerosis
- endoplasmic reticulum stress
- single cell
- oxidative stress
- electronic health record
- machine learning
- mesenchymal stem cells
- diabetic rats
- cell proliferation
- big data
- type iii
- data analysis