Immune Checkpoint Inhibition-related Neuroinflammation Disrupts Cognitive Function.

Onwodi V IfejeokwuAn DoSanad M El KhatibNhu H HoAngel ZavalaShivashankar Othy Munjal M Acharya

Published in: bioRxiv : the preprint server for biology (2024)

Despite the superior therapeutic efficacy of immune checkpoint inhibition (ICI) for cancers, its undesired effects on brain function are not fully understood. Here, we demonstrate that combination ICI elevates neuroinflammation, activates microglia, leading to detrimental neurodegenerative and neurocognitive sequelae.

Keyphrases

cerebral ischemia
lipopolysaccharide induced
traumatic brain injury
lps induced
inflammatory response
cognitive impairment
white matter
bipolar disorder
resting state
subarachnoid hemorrhage
neuropathic pain
multiple sclerosis
brain injury