Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow-Derived Macrophages.

Min Wu Lingxiang Wu Wei Wu Mengyan Zhu Jianyu Li Ziyu Wang Jie Li Rong Ding Yuan Liang Liangyu Li Tingting Zhang Bin Huang Yun Cai Kening Li Lu Li Rui Zhang Baoli Hu Fan Lin Xiuxing Wang Siyuan Zheng Jian Chen Yongping You Tao Jiang Junxia Zhang Hongshan Chen Qiang-Hu Wang

Published in: Cancer research (2023)

Bone marrow-derived macrophages phagocytose glioblastoma cells to form double-positive cells, dually expressing macrophage and tumor signatures that are transformed into M2-like macrophages and drive immunosuppression.

Keyphrases

induced apoptosis
cell cycle arrest
mesenchymal stem cells
adipose tissue
cell death
gene expression
dna methylation
cell proliferation