Nutraceuticals: A Promising Therapeutic Approach in Ophthalmology.
Carlos Rodrigo Castro-CastanedaFrancisco Altamirano-LamarqueAlan Gabriel Ortega MacíasFrancisco J Santa Cruz-PavlovichAlejandro Gonzalez-De la RosaJuan Armendáriz-BorundaArturo SantosLuis Carlos Rosales-RiveraPublished in: Nutrients (2022)
Oxidative stress represents one of the main factors driving the pathophysiology of multiple ophthalmic conditions including presbyopia, cataracts, dry eye disease (DED), glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy (DR). Currently, different studies have demonstrated the role of orally administered nutraceuticals in these diseases. For instance, they have demonstrated to improve lens accommodation in presbyopia, reduce protein aggregation in cataracts, ameliorate tear film stability, break up time, and tear production in dry eye, and participate in the avoidance of retinal neuronal damage and a decrease in intraocular pressure in glaucoma, contribute to the delayed progression of AMD, or in the prevention or treatment of neuronal death in diabetic retinopathy. In this review, we summarized the nutraceuticals which have presented a positive impact in ocular disorders, emphasizing the clinical assays. The characteristics of the different types of nutraceuticals are specified along with the nutraceutical concentration used to achieve a therapeutic outcome in ocular diseases.
Keyphrases
- diabetic retinopathy
- age related macular degeneration
- optic nerve
- optical coherence tomography
- oxidative stress
- cataract surgery
- dna damage
- artificial intelligence
- high throughput
- machine learning
- protein protein
- blood brain barrier
- signaling pathway
- small molecule
- amino acid
- brain injury
- reduced graphene oxide
- endoplasmic reticulum stress