Hypertriglyceridemia (HTG) is a feature of numerous metabolic disorders including dyslipidemias, metabolic syndrome, and diabetes mellitus type 2 and can increase the risk of premature coronary artery disease. HTG may also be due to genetic factors (called primary HTG) and particularly the severe/extreme HTG (SEHTG), which is a usually rare genetic disorder. Even rarer are secondary cases of SEHTG caused by autoimmune disease. This review considers the causes of SEHTG, and their management including treatment with low density lipoprotein apheresis and analyzes the original findings.
Keyphrases
- metabolic syndrome
- coronary artery disease
- low density lipoprotein
- genome wide
- early onset
- climate change
- machine learning
- multiple sclerosis
- dna methylation
- heart failure
- insulin resistance
- drug induced
- copy number
- skeletal muscle
- cardiovascular events
- deep learning
- combination therapy
- atrial fibrillation
- uric acid
- replacement therapy
- glycemic control
- weight loss
- neural network