Validation of dermatopathological criteria to diagnose cutaneous lesions of mastocytosis: importance of KIT D816V mutation analysis.
J GebhardH-P HornyT KristensenSigurd Broesby-OlsenAlexander ZinkTilo BiedermannKnut BrockowPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2022)
MPCM can be predicted by major and minor criteria combined in a scoring model. Presence of D816V mutation in FFPE skin and MC density > 27/HPF are >95%-specific major criteria for MPCM. MC densities 12/HPF, interstitial MC, clusters and basal pigmentation are minor criteria.
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