Alterations in sperm RNAs persist after alcohol cessation and correlate with epididymal mitochondrial dysfunction.

Alexis N Roach Sanat S BhadsavleSamantha L HigginsDestani D DerricoAlison BaselKara N ThomasMichael C Golding

Published in: Andrology (2023)

Our data reveal that alcohol-induced epididymal mitochondrial dysfunction and differences in sperm noncoding RNA content persist after alcohol withdrawal. Further, differences in mir-196a and sperm mitochondrial DNA copy number may serve as viable biomarkers of adverse alterations in the sperm-inherited epigenetic program.

Keyphrases

mitochondrial dna
copy number
genome wide
dna methylation
alcohol consumption
cell proliferation
long non coding rna
gene expression
quality improvement
single cell
machine learning
data analysis