Diabetic kidney disease induces transcriptome alterations associated with angiogenesis activity in human mesenchymal stromal cells.

Xiaohui BianSabena M ConleyAlfonso EirinEric A Zimmerman ZuckermanAnastasia L SmithCody C GowanZachary K SnowTambi JarmiHoussam FarresYoung M ErbenAlbert G HakaimMatthew A DietzAbba C ZubairSaranya P WylesJoy V WolframLilach O LermanLaTonya J Hickson

Published in: Stem cell research & therapy (2023)

MSC from individuals with DKD show angiogenic transcriptome alterations compared to age-matched controls. However, angiogenic repair potential may be preserved, supporting autologous MSC interventions to treat conditions requiring enhanced angiogenic activities such as DKD, diabetic foot ulcers, and critical limb ischemia.

Keyphrases

endothelial cells
wound healing
bone marrow
rna seq
single cell
gene expression
genome wide
type diabetes
physical activity
vascular endothelial growth factor
induced pluripotent stem cells
stem cells
mesenchymal stem cells
dna methylation
platelet rich plasma
human health