LLPS of DDR1 Counteracts the Hippo Pathway to Orchestrate Arterial Stiffening.
Jiayu LiuJin WangYueqi LiuSi-An XieJianrui ZhangChuanrong ZhaoYuan ZhouWei PangWeijuan YaoQin PengXiaohong WangJing ZhouPublished in: Circulation research (2022)
These findings identify DDR1 as a mediator of YAP activation by mechanical and chemical stimuli and demonstrate that DDR1 regulates LATS1 phosphorylation in an liquid-liquid phase separation-dependent manner.
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