Stereodivergent Synthesis of Alkaloid (±)-223A and (±)-6- epi -223A via Rh-Catalyzed Hydroformylation Double Cyclization.
Wen-Wei HuangJui-Teng ChengWei-Ting HsiaoWen-Hua ChiouPublished in: The Journal of organic chemistry (2024)
A stereodivergent approach toward total syntheses of Dendrobatid alkaloids 223A and 6- epi -223A is described. The approach features a concise construction of an indolizidine skeleton by Rh-catalyzed domino hydroformylation double cyclization and sequential stereocontrolled transformations such as reductive alkylation or anti -selective α-alkylation of the 5-oxoindolizidine. These stereoselective reactions afford the desired stereochemistry in the targets.
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