Photosensitizer-Conjugated Bi2Te3 Nanosheets as Theranostic Agent for Synergistic Photothermal and Photodynamic Therapy.
Jing BaiXiaodan JiaYudi RuanChao WangXiue JiangPublished in: Inorganic chemistry (2018)
Phototherapy, including photothermal therapy (PTT)/photodynamic therapy (PDT), is usually considered as a promising strategy for cancer treatment due to its noninvasive and selective therapeutic effect by laser irradiation. A light-activatable nanoplatform based on bovine serum albumin (BSA)-coated Bi2Te3 nanosheets conjugated with methylene blue (MB) was successfully designed and constructed for bimodal PTT/PDT combination therapy. The resultant nanoconstruct (BSA-Bi2Te3/MB) exhibited high stability in various physiological solutions and excellent biocompatibility. Especially, the nanoconstruct not only possessed strong near-infrared absorption and high photothermal conversion as a photothermal agent for efficient tumor ablation but also could successfully load photosensitizer for PDT of tumor. When exposed to laser irradiation, tumors in mice with BSA-Bi2Te3/MB injection were completely eliminated without recurrence within 15 d, demonstrating the potential of the nanoconstruct as a bimodal PTT/PDT therapeutic platform for cancer treatment.
Keyphrases
- photodynamic therapy
- fluorescence imaging
- combination therapy
- quantum dots
- reduced graphene oxide
- cancer therapy
- high speed
- wastewater treatment
- metal organic framework
- radiation induced
- radiation therapy
- skeletal muscle
- free survival
- adipose tissue
- high fat diet induced
- drug delivery
- climate change
- drug release
- wild type