A case report on severe nivolumab-induced adverse events similar to primary sclerosing cholangitis refractory to immunosuppressive therapy.

Yuya HirasawaKiyoshi YoshimuraHiroto MatsuiYutaro KubotaHiroo IshidaJun AraiMasashi SakakiNao OguroMidori ShidaMakoto TaniguchiKazuyuki HamadaHirotsugu AriizumiTomoyuki IshiguroRyotaro OhkumaTakehiko SambeAtsushi HoriikeChiyo K ImamuraEisuke ShiozawaSatoshi WadaJunji TsurutaniSanju IwamotoNaoki UchidaYuji KiuchiGenshu TateShinichi KobayashiTakuya Tsunoda

Published in: Medicine (2021)

This is the first case report on the ineffectiveness of triple immunosuppressant combination therapy recommended by the guidelines for immune-related hepatotoxicity. It is necessary to develop more appropriate treatment for severe sclerosing cholangitis-like irAE based on the robust evidence.

Keyphrases

combination therapy
drug induced
case report
early onset
high glucose
clinical practice
oxidative stress
replacement therapy
mesenchymal stem cells
stress induced