MEK inhibition sensitizes pancreatic cancer to STING agonism by tumor-cell intrinsic amplification of type I interferon signaling.

Razmik Ghukasyan Keke Liang Kevin Chau Luyi Li Charlotte Chan Evan R Abt Thuc Le Joon Y Park Nanping Wu Alykhan M Premji Robert Damoiseaux Tony Luu Amanda Labora Khalid Rashid Jason M Link Caius G Radu Timothy R Donahue

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Our results highlight the cytotoxic effects of STING agonism on PDAC cells that are independent of tumor immunity, and that these therapeutic benefits of STING agonism can be synergistically enhanced by MEK inhibition.

Keyphrases

induced apoptosis
pi k akt
cell cycle arrest
endoplasmic reticulum stress
single cell
signaling pathway
dendritic cells
oxidative stress
immune response
mesenchymal stem cells
nucleic acid