Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation.
Xiaoxia YeMingming ZhuXiaohang CheHuiyang WangXing-Jie LiangChunfu WuXue XueJing Y YangPublished in: Journal of neuroinflammation (2020)
These data reveal that LPS-induced neuroinflammation in N9 microglial cells is associated with the inhibition of autophagic flux through the activation of the PI3KI/AKT/MTOR pathway, while enhanced microglial autophagy downregulates LPS-induced neuroinflammation. Thus, this study suggests that promoting the early stages of autophagy might be a potential therapeutic approach for neuroinflammation-associated diseases.
Keyphrases
- lps induced
- inflammatory response
- signaling pathway
- cell death
- induced apoptosis
- lipopolysaccharide induced
- cell proliferation
- cell cycle arrest
- endoplasmic reticulum stress
- toll like receptor
- oxidative stress
- pi k akt
- genome wide
- neoadjuvant chemotherapy
- electronic health record
- traumatic brain injury
- radiation therapy
- neuropathic pain
- single cell
- dna methylation
- data analysis
- brain injury
- blood brain barrier
- cognitive impairment
- subarachnoid hemorrhage
- cerebral ischemia
- locally advanced