Enhancing thermostability and removing hemin inhibition of Rhodopseudomonas palustris 5-aminolevulinic acid synthase by computer-aided rational design.

Zijian TanJing ZhaoJiuzhou ChenDeming RaoWenjuan ZhouNing ChenPing ZhengJibin SunYanhe Ma

Published in: Biotechnology letters (2018)

H29R and H15K showed high thermostability, reduced hemin inhibition and slightly high activity, indicating that these two variants are good candidates for bioproduction of ALA.

Keyphrases

photodynamic therapy
copy number
dna methylation