The relationship between CD204 M2 -polarized tumour-associated macrophages (TAMs), tumour-infiltrating lymphocytes (TILs), and microglial activation in glioblastoma microenvironment: a novel immune checkpoint receptor target.
Maher KurdiBadrah Saeed AlghamdiNadeem Shafique ButtSaleh Salem BaeesaPublished in: Discover. Oncology (2021)
. These findings suggest that TAMs masks tumour cell and suppress T-cell tumoricidal functions via immunomodulatory mechanisms. Blockade of the CD204-TAM receptor may prevent this mechanism and allow the evolution of TILs.